In Vivo PK

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In vivo PK

Eviogen offers in vivo PK, toxicokinetics (TK) and formulation analysis services to support drug discovery and preclinical development for small molecules, peptides, nucleosides/nucleotides and biologics. Studies are conducted in state-of-art animal facilities and follow IAEC-approved study protocols.

  • Formulation screening
  • Cassette and single compound PK in mouse, rat, rabbit, mini pig, guinea pig, dog, monkey
  • Tissue distribution.
  • Special dosing routes: infusion, intratracheal, intra-colon, etc.
  • Portal vein and bile duct cannulation.
  • Quantitative analysis of samples with various biological matrices .
  • Microdialysis for compound unbound concentration measurement .
  • Ussing chamber for evaluating intestinal permeability, metabolism and transporters interaction .

In vivo PK

PK/PD studies help confirm the test article exposure and biomarker level in systemic circulation and tissues, particularly target organs and understand the correlation of the test article exposure with its PD effect using diseased or healthy animal models. The PK and bioanalytical teams analyze the samples taken from in vivo work to determine test article exposure and/or biomarker level. The quantification of biomarkers is conducted by the in vitro biology and ex vivo pharmacology teams.

  • Subcutaneous tumor xenograft model.
  • Orthotopic xenograft model .
  • Metastasis models.

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