In vivo Pharmacology
Understand your lead candidate’s behaviour within the whole organism and accelerate your in-vivo biology across therapeutic areas. The In-vivo Pharmacology & Biology department at eviogen has state-of-the-art infrastructure and the expertise to conduct PK-PD and efficacy studies in various disease models related to oncology, metabolic disorder, pain, inflammation and respiratory disease.
Immunocompromised strains of mice, rodents and rabbits are housed in our dedicated animal facility for in-vivo pharmacology. Our animal studies for in-vivo pharmacology are conducted under the guidance of the Institutional Ethics Committee and are overseen by experts in each of the models and disease areas.
Oncology
Subcutaneous tumor xenograft model.
Orthotopic xenograft model .
Metastasis models.
Pain pharmacology
Formalin test in rats
Writhing test.
Metabolic Disorders
STZ induced diabetes.
Multiple Low dose STZ diabetes .
High fat Diet + low dose of STZ
Anti-obesity activity .
Anorectic activity.
Cholesterol diet induced .
Atherosclerosis in rabbits .
Triton induced hyperlipidaemia .
Cardiovascular disorders
Anti - hypertensive activity (Renal hypertension)
Isoproterenol induced Myocardial Necrosis .
DOCA-salt induced Hypertension .
2K/1C renal Hypertension .
Diuretic activity (LIPSCHITZ test).
Neuropharmacology
Open field test .
Scopolamine-induced amnesia .
ICV surgery .
Middle Cerebral Artery Occlusion & Reperfusion .
Antigliomo — Brain tumor model .
MPTP model of Parkinsonism .
Inflammation
LPS induced pulmonary inflammation (Rat) .
Carrageenan induced paw edema (Rat & Mouse) .
Cytokine Induced Inflammation (Rat & Mouse)
Bleomycin Induced Pulmonary Fibrosis (Rat) .